Overdose Spike Response Framework: Provides a comprehensive guide for local health departments to proactively plan, coordinate with multi-sector partners, and execute effective public health responses to rapid increases in overdose events, tailored to local context and resource availability.

Public Health and Safety Team (PHAST) Toolkit: This document provides guidance for data-driven overdose response coordination among public health, criminal justice, law enforcement, and first responders. The Public Health and Safety Team (PHAST) Toolkit was developed to assist city, county, or municipal public health and public safety agencies interested in working collaboratively to reduce overdose deaths.

Massachusetts Drug Supply Data Stream (MADDS): The Massachusetts Drug Supply Data Stream (MADDS) is a community‑public health‑public safety collaboration that analyzes seized illicit drug samples, especially fentanyl and novel synthetics, to provide timely, aggregate surveillance data that inform interventions and harm reduction strategies.

Pennsylvania Department of Health Office of Drug Surveillance and Misuse Prevention EpiCenter Alert Guidance Document: Provides a structured framework and best practices for setting up, configuring, and managing overdose alert notifications within the EpiCenter syndromic surveillance platform to ensure timely, actionable public health responses.

State of Nevada’s Syndromic Surveillance Alert & Investigation Plan: Outlines a strategic framework for integrating near real‑time data (via BioSense, ESSENCE, emergency department and OTC sales monitoring) to enhance situational awareness, outbreak detection, and public health responsiveness across state, local, tribal, and territorial jurisdictions.

Michigan Department of Health and Human Services Michigan Syndromic Surveillance System (MSSS) User Manual: Provides comprehensive guidance on utilizing the MSSS platform for real-time monitoring of emergency department and urgent care visit data, enabling public health officials to detect and respond to unusual increases in symptom presentations.

Montgomery County Public Health Incident Action Plan Community Overdose Action Team (COAT): Outlines a coordinated, multi-agency response to address a surge in opioid overdoses, detailing objectives, resource allocations, and safety protocols for the operational period.

CDC Program Evaluation Framework Action Guide: A comprehensive resource to assist new or early career evaluators with applying the CDC Program Evaluation Framework across a range of programs and settings.

Logic models: A tool for effective program planning, collaboration, and monitoring: This guide, an installment in a four-part series on logic models, describes the role of logic models in effective program planning, collaboration, and monitoring.

Updated Guidelines for Evaluation Public Health Surveillance Systems: This report provides updated guidelines for evaluating surveillance systems based on CDC’s Framework for Program Evaluation in Public Health, research and discussion of concerns related to public health surveillance systems, and comments received from the public health community.

Homeland Security Exercise and Evaluation Program (HSEEP): Provides a set of fundamental principles for exercise programs, as well as a common approach to program management, design and development, conduct, evaluation, and improvement planning.

Evaluation: A Systematic Approach: Provides a comprehensive, theory-driven framework for designing, conducting, and applying program evaluations to assess effectiveness, improve implementation, and inform decision-making in public policy and social programs.

The U.S. Department of Health and Human Services (HHS) Overdose Prevention Strategy: Outlines a comprehensive, evidence-based approach encompassing primary prevention, harm reduction, treatment, and recovery to reduce overdose-related harms by promoting cross-sector collaboration, stigma-free care, and data-driven interventions tailored to evolving substance use trends.

Opportunities for Prevention and Intervention of Opioid Overdose in the Emergency Department: Article highlighting how emergency physicians not only reverse overdoses but also have a critical opportunity to engage in preventive strategies, such as safer prescribing practices, naloxone distribution, and linkage to opioid use disorder treatment

Points of Contact for Each HIDTA Area: The latest contact information for Drug Intelligence Officers (DIOs) and Public Health Analysts (PHAs)

Synthea: Open-source synthetic patient generator that models the medical history of synthetic patients.

This approach allows public health teams to simulate overdose trends and test how policy or system changes may influence overdose anomaly detection without using real patient data.

Legality of Drug Checking Equipment in the United States: Provides a comprehensive overview of state laws governing health data exchange for public health purposes, highlighting key variations in data sharing authority, consent requirements, and data use agreements across all U.S. states.

Understanding the spatiotemporal evolution of opioid overdose events using a regionalized sequence alignment analysis: This study introduces a novel regionalized sequential alignment analysis that examines opioid overdose events by comparing the spatiotemporal trajectories of overdose patterns across neighborhoods with similar socioeconomic characteristics, enabling finer-grained detection of evolving local dynamics.